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All Packages | Biopharma Lab Package
Decisive Biologics Data for Superior Therapies
Simplify the development of biologic-based molecules to detect, treat and even prevent disease
Simplify the development of biologic-based molecules to detect, treat and even prevent disease
Complete characterization of molecular binding and structure stability
Structure stability, binding affinity, and reaction kinetics are basic chemical characteristics required to understand the functional and therapeutic properties of a drug. Isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC) provide reproducible measurements with sensitive testing to inform critical decisions.
Forming effective vaccine therapies requires characterizing the thermal stability of the virus coat proteins in solution, which can be most effectively studied with the Nano DSC. Fundamental information about the molecular interactions driving virus/cell binding processes can be obtained using ITC.
For gene therapy, the Nano DSC and ITC are implemented in discovery, formulation, and process control. These techniques help characterize and monitor:
- Drug product cargo loading
- Serotype
- Impurities (dsRNA)
- Binding specificity
- Capsid stability
- Batch-to-batch variability.
Unprecedented efficiency for confident decision making
Biologics testing on the Nano DSC and Affinity ITC requires minimal or zero sample preparation, which saves time, reduces sample preparation errors, and eliminates optimization of background chemistry (i.e. fluorescence tuning, signal saturation, antibody specificity, etc.).
When automated, the Nano DSC and Affinity ITC are efficiency-increasing tools that aid in next-level quality design and offer peace of mind throughout development and into clinical phases.
The Affinity ITC is a powerful tool for measuring a wide variety of molecular interactions. It provides both inexperienced and advanced ITC users the highest confidence in generating superior ITC data.
Temperature Stability (Standard Volume): 50 µ °C at 25 °C
Features of the Affinity ITC
- AccuShot™ delivers the titrant to the right location for the best mixing
- FlexSpin™ provides innovative slow speed stirring, efficient mixing and highest sensitivity
- Fully automated, user-selectable system cleaning routines eliminate run-to-run contamination
- Intelligent Hardware Positioning for precise reliable injections
- Solid-state active heating and cooling for true isothermal temperature control
- Choice of standard volume (1.0 mL) or low volume cells (190 µL)
- Industry proven 96-well, temperature-controlled liquid handling autosampler.
- Autosampler can be included with initial purchase or added at a later date
- Powerful ITCRun and NanoAnalyze for the most comprehensive suite of tools for method optimization, model fitting, batch analysis, graphing and data export.
The Nano DSC differential scanning calorimeter is designed to characterize the molecular stability of dilute in-solution biomolecules. The Nano DSC obtains data using less sample than competitive designs. Solid-state thermoelectric elements are used to precisely control temperature and a built-in precision linear actuator maintains constant or controlled variable pressure in the cell. Automated, unattended continuous operation with increased sample throughput is achieved with the optional Nano DSC Autosampler.
Temperature Range: -10 °C to 130 °C
The Nano ITC Standard Volume and Nano ITC Low Volume isothermal titration calorimeters are designed to provide maximum sensitivity and flexibility for the study of biomolecular binding. Both instruments use solid state thermoelectric heating and cooling systems to precisely control temperature, and have the same flexible injection syringe assemblies for efficient and accurate delivery of titrant. The true isothermal power compensation design of the Nano ITC instruments provides the highest sensitivity and flexibility for an ultrasensitive ITC analyzing biological samples in-solution.
Temperature Range (Standard Volume): 2 °C to 80 °C
Technology
Streamline Preclinical Development With Efficient Technologies
Biopharmaceuticals, distinct from small molecule drugs, include a wide variety of therapeutic products derived from living organisms or produced from biotechnology sources (vaccines, gene therapies, and recombinant proteins).
Researchers like you need precise knowledge of key chemical details when it comes to candidate biotherapeutics and biologics-based molecules. The Nano DSC and Affinity ITC from TA Instruments measure changes in structural stability and quantify molecular binding without modification. Samples and drug products are label-free and do not rely on immobilization on the surface of a chip or sensor.
